Role of Antiepileptic Drugs in Migraine Prevention

Antiepileptic Drugs and Migraine

Cost-effectiveness of antiepileptic drugs in migraine prophylaxis.

OBJECTIVE To analyze the cost-effectiveness of antiepileptics in migraine prophylaxis. METHODS A cost-effectiveness analysis was performed using efficacy data from three recent, double-blind, placebo-controlled, clinical trials of antiepileptic drugs studied for migraine prevention and cost data. Two measures of cost-effectiveness were used: cost per headache prevented and the cost-equivalent...

Preventive Agents for Migraine: Focus on the Antiepileptic Drugs

Migraine is among the 10 most disabling disorders worldwide. It is characterized by episodes of moderate or severe headaches with various degree of disability, resulting in a considerable health burden upon the sufferers and their family. The objective of this article is to review the use of prophylaxis with antiepileptic drugs. Particular focus is given to their mechanism of action, metabolism...

Antiepileptic Drugs

Antiepileptics are a very important class of medications, and the number of these drugs available for clinical use has increased dramatically in the last decade. The pharmacology and indications for use in a variety of physiatric patient groups are comprehensively and systematically reviewed.

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs.

Epilepsy, one of the most common neurologic disorders, is a major public health issue. Despite more than 20 approved antiepileptic drugs (AEDs), about 30% of patients are refractory to treatment. An important characteristic of pharmacoresistant epilepsy is that most patients with refractory epilepsy are resistant to several, if not all, AEDs, even though these drugs act by different mechanisms....